Integrated analysis of long non-coding RNAs and mRNAs associated with malignant transformation of gastrointestinal stromal tumors

Abstract Malignant transformation of gastrointestinal stromal tumors (GISTs) is correlated with poor prognosis; however, the underlying biological mechanism not well understood. In present study, low-risk (LR) GISTs, GISTs categorized as high-risk based on tumor size (HBS), and mitotic rate (HBM) were collected for RNA sequencing. Candidate hub lncRNAs selected by Oncomine analysis. Expression a lncRNA, DNM3OS, its correlation patients’ prognosis analyzed using FISH staining, followed determination function mechanism. Our results revealed series key pathways involved in malignant GISTs. analysis tight association between clinical signatures DNM3OS suggested that lncRNA Hippo signaling pathway. addition, was upregulated HBS, HBM, HBS/M GIST worse patients promoted cell proliferation mitosis regulating expression GLUT4 CD36. Collectively, these improve our understanding unveil